Table 1 Studied scenarios for drug aerosol supply to the rat capnoperitoneum phantoms (RCP).

Phantom (–)	Volume (mL)	Flow rate (SL/min)	Pressure drop (mbar)	Residence time^a (s)	Purging direction (–)	Charge^b (–)
Virtual RCP	146.2 ± 0.00	1.0	n/a	8.77 ± 0.00	Top-down, bottom-up	n/a
		3.0		2.92 ± 0.00	Top-down, bottom-up
		5.0		1.75 ± 0.00	Top-down, bottom-up
Physical RCP	130.85 ± 3.89	1.0	0.08 ± 0.029	7.85 ± 0.24	Top-down	+/−, +
		3.0	0.60 ± 0.000	2.62 ± 0.08	Top-down	+/−, +
		5.0	1.72 ± 0.076	1.57 ± 0.05	Top-down	+/−, +
Alternative RCP	134.65 ± 0.43	1.0	0.07 ± 0.029	8.08 ± 0.03	Top-down	+
		3.0	0.43 ± 0.058	2.69 ± 0.01	Top-down	+
		5.0	0.88 ± 0.029	1.62 ± 0.01	Top-down	+

^aRatio of inner RCP volume and air/aerosol flow rate that describes the mean period of time a discrete volume passes the RCP.
^bi.e., aerosol charge condition; + / − … bipolar neutralized aerosol, + … macroscopic positively charged aerosol.

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