Figure 1
From: Drug repurposing for coronavirus (SARS-CoV-2) based on gene co-expression network analysis
The overall workflow of the proposed method. In this method, a network-based approach is applied to drug repurposing for coronavirus disease treatment. (a) At first, a transcriptome profile for healthy (control) and SARS-CoV-infected samples were taken from the GEO database with the accession number GSE1739. (b) Then, after identifying differentially expressed genes in the control and disease groups, the gene co-expression network is reconstructed, and two significant gene modules are discovered from the co-expression network. (c) Next, for every gene module, the TF-miRNA-TG network is reconstructed independently. The information of TFs-miRNAs, TFs-TGs, and miRNAs-TGs regulations are taken from the TransmiR42, TRRUST39, and miRWalk40 databases, respectively. (d) Afterward, Drug-gene and Drug-TF networks are reconstructed for TF-miRNA-TG networks independently. (e) Finally, 19 drugs are proposed as candidate drugs for coronavirus treatment.
