Figure 3
From: Neurofilaments can differentiate ALS subgroups and ALS from common diagnostic mimics
Biomarker correlation to survival, survival analyses in clinical symptom onset and genotype groups, biomarker ratios and ALSFRS-R in ALS patients. (A) Correlation between plasma NFL and survival after symptom onset stratified by spinal and bulbar symptom onset. (B) Kaplan–Meier survival analysis for spinal onset versus bulbar onset ALS patients. (C) Correlation between plasma NFL and survival after symptom onset for participants in the total ALS cohort. (D) Kaplan–Meier survival analysis between patients with no known mutation, SOD1 mutation and C9orf72HRE mutation (p-value presented for overall comparisons). (E) Ratios and correlations between plasma NFL and CSF NFL stratified for spinal onset and bulbar onset ALS patients. (F) Correlation between CSF NFL and CSF pNFH for participants in the total ALS cohort. (G) Correlation between ALSFRS-R and plasma NFL in ALS patients. (H) Correlation between ALSFRS-R and survival after symptom onset in ALS patients.
