Figure 7
From: CyFi-MAP: an interactive pathway-based resource for cystic fibrosis
Sorting endosome in wt-CFTR (A) and F508del-CFTR (B) submaps. In the image (A), is possible to see wt-CFTR arriving at the sorting endosome [21] and the possible pathways to follow, either recycling [22], [23] and [24], or degradation [25] in orange lines. Bellow in image (B), rF508del-CFTR in red arrives at the endosome [10] in a complex with ubiquitin (represented with Ub) where several proteins target it to degradation directly, representing the low/absence of recycling of this protein. The proteins highlighted in yellow are unique to F508del-CFTR.
