Figure 4
From: Biocompatible N-acetyl-nanoconstruct alleviates lipopolysaccharide-induced acute lung injury in vivo
Effects of Nano/NAC on MDA contents in BALF and the intracellular ROS levels, GSH/GSSG ratios, and SOD activities in lung tissues. (A, B) The LPS group showed significantly higher MDA contents and ROS levels than the control group. The LPS + NAC group showed significantly lower MDA contents and ROS levels than the LPS group. The LPS + Nano/NAC group showed significantly lower MDA contents and ROS levels than the LPS + NAC group. (C, D) The LPS group showed significantly lower GSH/GSSG ratios and SOD activities than the control group. The LPS + NAC group showed significantly higher GSH/GSSG ratios and SOD activities than the LPS group. The LPS + Nano/NAC group showed significantly higher GSH/GSSG ratios and SOD activities than the LPS + NAC group. The data shown are expressed as the mean ± SE (n = 6 rats/group). **P < 0.05 versus the control group; *P < 0.05 versus the LPS group; #P < 0.05 versus the LPS + NAC group. Nano Nanoconstruct, NAC N-acetylcysteine, MDA Malondialdehyde, BALF Bronchoalveolar lavage fluid, ROS Reactive oxygen species, GSH Reduced glutathione, GSSG Oxidized glutathione, SOD Superoxide dismutase, LPS Lipopolysaccharide.
