Figure 7
From: Biocompatible N-acetyl-nanoconstruct alleviates lipopolysaccharide-induced acute lung injury in vivo
Effects of Nano/NAC on iNOS expression in lung tissues. Lung sections obtained from the control group showed minimal iNOS staining. In contrast, lung sections from the LPS group showed significantly higher iNOS staining than those derived from the control group. The increased iNOS staining in the LPS group was markedly attenuated by NAC or Nano/NAC co-treatment, with a greater significant difference observed in the Nano/NAC group (immunohistochemical staining for iNOS, × 200). Quantitative analysis showed that iNOS expression was significantly higher in the LPS group than in the control group. However, iNOS expression was significantly decreased by NAC or Nano/NAC co-treatment, with a greater significant difference observed in the Nano/NAC group. The data shown are expressed as the mean ± SE (n = 6 rats/group). **P < 0.05 versus the control group; *P < 0.05 versus the LPS group; #P < 0.05 versus the LPS + NAC group. Nano Nanoconstruct, NAC N-acetylcysteine, iNOS Inducible nitric oxide synthase, LPS Lipopolysaccharide.
