Figure 8
From: Hotspots for mutations in the SARS-CoV-2 spike glycoprotein: a correspondence analysis
Cartoon presentation of the stalk of the SARS-CoV-2 spike glycoprotein. The left panel shows the stalk of the SARS-CoV-2 spike glycoprotein. The furin cleavage motif is discriminated against by colored ribbons; other ribbons were hidden for better presentation. The positions of the different boxes of the furin cleavage motif are illustrated by vertical lines; the color scheme is based on reference38. The different parts of the furin binding site are assigned by different colors of ribbons, and the red arrow shows the exact cleavage site between residues of Arg685 and Ser686. The right panel shows the network interaction of the furin binding site and other residues in the trimeric structure. The ellipses are residues of the binding site and diamonds are the residues on the nearby chain. The filled color is based on Z-score, and edges are different interactions (color key at the bottom). The cartoon representation of the protein is generated by Chimera (ver. 1.13); the network in the left panel is made by Cytoscape (ver. 3.7.2).
