Figure 3 | Scientific Reports

Figure 3

From: Structural modification of fentanyls for their retrospective identification by gas chromatographic analysis using chloroformate chemistry

Figure 3

Optimization of reaction parameters for the reaction between fentanyl and acetylfentanyl with TrocCl (n = 6, ± standard deviation for each bar graph presented). (a) Effect of the nature of the base in the production of Troc-norfentanyl (teal bars) and Troc-nor-acetylfentanyl (red bars) at 60 °C at t = 3 h.; (b) effect of temperature on the reaction demonstrating the increase of the Troc-norfentanyl products as temperature is increased; (c) effect of solvent on the reaction showing its higher performance in DCM and ethyl acetate (EtOAc); (d) effect of time on the reaction.

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