Figure 1
From: Losartan improves intestinal mucositis induced by 5-fluorouracil in mice
Histopathological analysis of intestinal segments of the duodenum, jejunum, ileum and colon of animals submitted to intestinal mucositis (IM) induced by 5-fluorouracil. Photomicrographs on a 100 μm scale demonstrated that the animals in the saline group maintained the integrity of the intestinal mucosa, with villi and crypts without damage, as well as the absence of inflammatory infiltrate. The 5-FU caused the loss of integrity, structure and shortening of the villi (black arrow), injury and disruption of the crypts with the presence of vacuolization (green arrow) and the presence of inflammatory infiltrate (red arrow). Losartan treatment at a dose of 50 mg/kg decreased the effects caused by 5-FU, improving the appearance of villi (red arrow) and crypts (black arrow).
