Figure 2
From: Losartan improves intestinal mucositis induced by 5-fluorouracil in mice
(A) Images of histological slides stained in H&E, of fragments of the jejunum of mice submitted to intestinal mucositis. Animals saline without IM (a), with intestinal mucositis induced by 5-FU, without treatment (b) and animals with IM, treated with losartan at a dose of 50 mg/kg. The measurement of villus integrity is represented by dashed lines in yellow and the size of crypts is represented by dashed lines in blue. Segments of the duodenum, jejunum and ileum were collected to measure the villus height (10 villi/lamina). Scale bars = 100 µm (B) and crypt depth measurements (C). The bars represent the mean ± SEM of 5 mice in each group. #p < 0.001 vs. saline group, **p < 0.001 vs. 5-FU group. One way ANOVA with Bonferroni post-test.
