Figure 3
From: Losartan improves intestinal mucositis induced by 5-fluorouracil in mice
(A) Effect of losartan on weight loss and (B) total leukocyte count in mice with 5-FU-induced intestinal mucositis (IM). (A) Weight assessment is shown as a percentage. The bars represent the mean ± SEM (n = 5) in each group. #p < 0.01 versus Saline group; *p < 0.001 versus group 5-FU (Two-way ANOVA analysis of variance followed by the Tukey test). (B) Animals with IM, group 5-FU, reduced the number of leukocytes compared to the saline group (**p < 0.0001). LOS 50 mg/kg significantly increased the number of cells when compared to the 5-FU group. *p < 0.0001 vs. group 5-FU; **p < 0.001 versus 5-FU group and ***p < 0.05 versus 5-FU group. ANOVA one-way test followed by the Tukey test.
