Figure 7
From: Losartan improves intestinal mucositis induced by 5-fluorouracil in mice
Representation of pharmacological modulation of the intestinal mucositis induced by 5-fluorouracil (5-FU) treated with the losartan. DNA damage due to 5-FU promotes the release of reactive oxygen species (ROS) and activates NF-κB that induces the expression of proinflammatory cytokines such as IL-1β and TNF-α, in addition, occurs the oxidative stress, which that together promote inflammation in the intestinal mucosa. Losartan was reducing NF-κB p65 in response the decreased of gene expression TWEAK/Fn14, reducing IL-1β and TNF-α and decreasing oxidative stress, therefore improving intestinal mucositis. TWEAK, Tumor necrosis factor (TNF)-like weak inducer of apoptosis; Fn14, Fibroblast growth factor-inducible 14; NF-κB p65, nuclear transcription factor kappa B.
