Table 1 Impact of the drinking temperature, the numbers of drinks/day and of demographic factors (age, BMI) on induction of nuclear anomalies reflecting DNA damage and disturbance of cell division in buccal cells. p-values from Poisson regression.

From: Investigations concerning the impact of consumption of hot beverages on acute cytotoxic and genotoxic effects in oral mucosa cells

Endpoint

Predictor

OR

95% CI

p-value

p for trend

MN cells

Tea temperature < 55 °C

1 (Ref)

   

55–59 °C

1.19

0.73–1.94

0.487

 

60–64 °C

1.17

0.70–1.94

0.553

 

65–69 °C

0.94

0.50–1.77

0.854

 

70 + °C

1.16

0.76–1.77

0.487

0.738

> 60 °C

1.00

0.74–1.35

0.979

 

Overweight (BMI 25–29.9)

0.99

0.71–1.40

0.971

 

Age (per decade)

0.95

0.79–1.15

0.611

 

# drinks/day

0.96

0.76–1.23

0.773

 

Total MN

Tea temperature < 55 °C

1 (Ref)

   

55–59 °C

1.20

0.75–1.90

0.448

 

60–64 °C

1.11

0.69–1.78

0.677

 

65–69 °C

1.23

0.71–2.11

0.461

 

70 + °C

1.24

0.83–1.83

0.290

0.385

> 60 °C

1.08

0.82–1.43

0.577

 

Overweight (BMI 25–29.9)

1.00

0.73–1.38

0.993

 

Age (per decade)

0.93

0.78–1.11

0.405

 

# drinks/day

1.00

0.80–1.26

0.986

 

Nuclear buds

Tea temperature < 55 °C

1 (Ref)

   

55–59 °C

1.03

0.74–1.43

0.882

 

60–64 °C

1.02

0.73–1.42

0.910

 

65–69 °C

1.26

0.88–1.81

0.210

 

70 + °C

1.25

0.95–1.63

0.106

0.146

> 60 °C

1.11

0.92–1.34

0.275

 

Overweight (BMI 25–29.9)

1.06

0.85–1.32

0.622

 

Age (per decade)

0.99

0.87–1.11

0.823

 

# drinks/day

0.96

0.82–1.13

0.638

 

BN

Tea temperature < 55 °C

1 (Ref)

   

55–59 °C

1.05

0.87–1.26

0.632

 

60–64 °C

0.92

0.76–1.12

0.412

 

65–69 °C

0.92

0.73–1.16

0.477

 

70 + °C

1.01

0.86–1.18

0.944

0.653

> 60 °C

0.94

0.84–1.05

0.262

 

Overweight (BMI 25–29.9)

0.95

0.83–1.08

0.435

 

Age (per decade)

0.92

0.86–0.99

0.026

 

# drinks/day

0.96

0.87–1.05

0.340

 
  1. MN Micronuclei, BN binucleated cells, OR Odds ratio, CI confidence interval.
  2. Number of participants per temperature group: < 55 °C (n = 21); 55–59 °C (n = 11); 60–64 °C (n = 15); 65–69 °C (n = 6); 70 + °C (n = 20).