Figure 1 | Scientific Reports

Figure 1

From: Evaluation of the effect of filtered ultrafine particulate matter on bleomycin-induced lung fibrosis in a rat model using computed tomography, histopathologic analysis, and RNA sequencing

Figure 1

Examples of inflammation and fibrosis in chest CT imaging and correlated histologic findings. (A) Consolidation is shown in the left lower region (white arrows). This consolidation in the differently reformatted CT image of the same rat and same lung region (yellow asterisk) is correlated with the histology section (blue asterisk, hematoxylin and eosin stain [H&E], X2). Histologic finding shows widening of interalveolar spaces with congestion. Several foci of lymphoid aggregates are also seen (box, H&E stain, X40). (B) Ground glass opacities (GGO) are shown in both lungs (white arrows). This GGO in a differently reformatted CT image of the same rat (yellow asterisk) is correlated with the histology section (blue asterisk, H&E stain, × 2). The histologic finding shows mild thickening of the alveolar septa with some histiocytes in the alveoli (in box, H&E stain, X20). (C) Centrilobular nodules are shown in both lungs (white arrows). Centrilobular nodules in differently reformatted CT image of the same rat (yellow asterisks) are correlated with the histology section (blue asterisks, H&E stain, X2). The histologic finding shows peribronchiolar inflammatory cell infiltration with thickening of the alveolar septa. Foamy histiocytes and pigmented macrophages are also seen in the alveoli (box, H&E stain, X100). (D) Bronchiectasis is in the right superior lobe (white arrows). Bronchiectasis in a differently reformatted CT image of the same rat in the right inferior lobe (yellow asterisks) is correlated with the histology section (blue asterisks, H&E stain, X2). The histologic finding shows cystic dilatation of bronchus with mucus secretion in the bronchus (box, H&E stain, X20). and (E) Multifocal linear densities in both lungs (white arrows). Multifocal linear densities in a differently reformatted CT image of the same rat in the left lower region (yellow asterisks) are correlated with the histology section (red asterisks, Masson's trichrome [MT] stain), X2). The histologic finding shows a confluent fibrotic band with obliteration of the alveoli (box, MT stain, X50).

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