Figure 2
Within-host selection is stronger for infections that last longer or have higher viral loads. (A) (Left panel) example of increased peak viral load period length. (Right) Probability that at least one transmitted virion has a specific advantageous single mutation, for different overall lengths of infection. Infection lengths were adjusted by increasing the length of the peak viral load period (left panel schematic). (B) (Left panel) example of decreased viral load. (Right) Probability that at least one transmitted virion has a specific single mutation, for different viral loads. Viral loads were adjusted by reducing the viral load by a constant factor over the entire course of infection (left panel schematic). For right panels, shaded areas represent ± SEM, n = 1000 simulations per condition, with a selection coefficient of 0.2 for the single mutant. Unless otherwise specified, simulation parameter values are those given in Table 1.
