Table 1 Parameter values used for intrahost SARS-CoV-2 evolutionary dynamics simulations.
Name | Description | Value | Source |
|---|---|---|---|
tg | SARS-CoV-2 replication cycle length | 12 h | |
Nb | Viral burst size-number of virions produced by each infected cell | 1000 | |
μ | Within-host SARS-CoV-2 mutation rate (per replication cycle, per site) | 10−5 | |
Ntrans | Number of virions transmitted to new host | 10 | |
R0 | Reproductive number-average number of new hosts infected by a single host infected with the mutant virus | 1.5 | Similar to the transmission advantage measured for B.1.1.75 |
σ | Number of new infected hosts (per day) | 50,000 | Similar to recently reported numbers for the US |
LLT | Mean (± standard deviation) of infection length in long-term SARS-CoV-2 shedders | 93.75 days ± 11.48 |
