Figure 2 | Scientific Reports

Figure 2

From: FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells

Figure 2

Endogenous FLT3-ITD localizes to the perinuclear Golgi region in AML cells. (a–c) MOLM-14 (a), MV4-11, Kasumi-6 (b), or RS4-11 cells (c) were stained for FLT3 (green) in conjunction with the indicated organelle markers (red or blue). TGN46 (Golgi marker, red), GM130 (Golgi marker, red); lectin-HPA (Golgi marker, blue); calnexin (ER marker, red); TfR (endosome marker, red); LAMP1 (lysosome marker, red). Bars, 10 µm. Note that FLT3-ITD accumulated in the Golgi region in AML cells.

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