Figure 5 | Scientific Reports

Figure 5

From: FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells

Figure 5

Model of FLT3-ITD signaling on intracellular compartments in AML cells. (Left) FLT3-wt normally moves to the PM along the secretory pathway for binding its ligand. Upon stimulation with FLT3 ligand at the cell surface, the wild-type receptor activates downstream molecules. (Right) FLT3-ITD is retained in the Golgi apparatus in AML cells. The mutant can activate kinases, such as AKT and ERK, in the perinuclear Golgi region, but not in the ER before reaching the PM. On the other hand, FLT3-ITD activates STAT5 in the ER, where it is newly synthesized.

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