Table 1 Demographic and laboratory data of 98 chronic hemodialysis patients and the comparisons among three tertile groups according to ADAMTS13 activity.
From: Association between ADAMTS13 deficiency and cardiovascular events in chronic hemodialysis patients
n | All patients | Low tertile | Middle tertile | High tertile | p |
|---|---|---|---|---|---|
98 | 32 | 33 | 33 | ||
ADAMTS13 activity (%) | 40.1 ± 22.8 | 18.9 ± 6.9 | 37.2 ± 4.5a | 66.1 ± 18.9ab | < 0.001 |
Age (years) | 62.6 ± 11.3 | 63.7 ± 8.2 | 62.4 ± 13.4 | 61.6 ± 11.7 | 0.8 |
Gender/female: n (%) | 39 (39.8) | 14 (43.8) | 10 (30.3) | 15 (45.5) | 0.4 |
Hemodialysis vintage (month) | 48.6 ± 34.1 | 58.0 ± 38.5 | 47.5 ± 33.4 | 40.4 ± 28.4 | 0.1 |
vWF antigen (%) | 172.9 ± 69.1 | 167.8 ± 63.5 | 176.5 ± 90.4 | 174.7 ± 49.3 | 0.9 |
vWF activity (%) | 153.7 ± 66.8 | 163.5 ± 78.3 | 138.9 ± 53.4 | 158.9 ± 66.0 | 0.4 |
White blood cell count (103/ml) | 6.27 ± 1.9 | 5.9 ± 1.9 | 6.3 ± 1.8 | 6.6 ± 2.0 | 0.3 |
Hemoglobin (g/dl) | 10.7 ± 1.0 | 10.6 ± 1.1 | 10.6 ± 1.0 | 10.9 ± 0.9 | 0.3 |
Platelet (103/ml) | 181.1 ± 41.5 | 167.6 ± 41.2 | 190.5 ± 50.6 | 184.8 ± 30.3 | 0.3 |
Albumin (g/dl) | 4.0 ± 0.2 | 4.0 ± 0.2 | 4.0 ± 0.2 | 3.9 ± 0.2 | 0.7 |
Blood urea nitrogen (mg/dl) | 56.7 ± 12.8 | 55.6 ± 13.5 | 54.2 ± 12.5 | 58.4 ± 12.2 | 0.4 |
Creatinine (mg/dl) | 10.0 ± 2.2 | 10.0 ± 1.9 | 10.2 ± 2.3 | 9.8 ± 2.3 | 0.8 |
Calcium (mg/dl), | 9.6 ± 0.8 | 9.8 ± 0.8 | 9.3 ± 0.7a | 9.5 ± 0.8 | 0.02 |
Phosphate (mg/dl) | 5.1 ± 1.2 | 5.0 ± 1.2 | 5.2 ± 1.3 | 5.1 ± 1.1 | 0.8 |
Uric acid (mg/dl) | 7.2 ± 1.3 | 7.0 ± 1.4 | 7.2 ± 1.4 | 7.6 ± 1.2 | 0.2 |
Glucose, fasting (g/dl) | 114.3 ± 48.8 | 98.8 ± 28.9 | 111.4 ± 43.5 | 132.2 ± 63.8a | 0.02 |
HbA1c (%) | 6.2 ± 1.4 | 5.7 ± 1.0 | 6.0 ± 1.2 | 7.0 ± 1.6ab | < 0.001 |
Cholesterol, total (mg/dl) | 161.6 ± 34.1 | 163.9 ± 33.5 | 154.7 ± 35.3 | 166.2 ± 33.4 | 0.3 |
Triglyceride (mg/dl) | 149.0 ± 80.5 | 115.1 ± 57.5 | 147.3 ± 83.5 | 183.4 ± 84.1a | 0.002 |
HDL (mg/dl) | 39.2 ± 13.0 | 41.9 ± 14.4 | 38.6 ± 12.4 | 37.0 ± 11.9 | 0.3 |
LDL (mg/dl) | 73.7 ± 24.4 | 76.3 ± 25.9 | 71.4 ± 24.0 | 73.4 ± 23.7 | 0.7 |
Ferritin (ug/l) | 311.3 ± 402.4 | 272.5 ± 205.8 | 294.2 ± 274.2 | 365.6 ± 605.7 | 0.6 |
Homocysteine (umole/l) | 23.2 ± 5.5 | 24.9 ± 5.8 | 22.9 ± 4.4 | 21.9 ± 5.9 | 0.07 |
hsCRP (mg/L) | 8.5 ± 15.6 | 9.1 ± 17.2 | 6.4 ± 9.4 | 10.1 ± 18.9 | 0.6 |
Medications: n (%) | |||||
Statin/ezetimibe | 33 (33.7) | 12 (37.5) | 10 (30.3) | 11 (33.3) | 0.8 |
Aspirin | 37 (37.8) | 13 (40.6) | 10 (30.3) | 14 (42.4) | 0.5 |
Clopidogrel | 23 (23.5) | 8 (25.0) | 6 (18.2) | 9 (27.3) | 0.7 |
Cilostazol | 5 (5.1) | 1 (3.1) | 2 (6.1) | 2 (6.1) | 0.8 |
Unfractionated heparin | 60 (61.2) | 19 (59.4) | 22 (66.7) | 19 (57.6) | 0.7 |
LMWH | 28 (28.6) | 12 (37.5) | 6 (18.2) | 10 (30.3) | 0.2 |
ACEI/ARB | 35 (35.7) | 14 (43.8) | 7 (21.2) | 14 (43.8) | 0.1 |
Beta blocker | 29 (29.6) | 11 (34.4) | 8 (24.2) | 10 (30.3) | 0.7 |
CCB | 50 (51.0) | 19 (59.4) | 15 (45.5) | 16 (48.5) | 0.5 |
Comorbidity: n (%) | |||||
DM | 60 (61.2) | 15 (46.9) | 20 (60.6) | 25 (75.8) | 0.06 |
Hypertension | 87 (88.8) | 27 (84.4) | 29 (87.9) | 31 (93.9) | 0.5 |
CHD | 32 (32.7) | 14 (43.8) | 6 (18.2) | 12 (36.4) | 0.08 |
CVD | 7 (7.1) | 1 (3.1) | 1 (3.0) | 5 (15.2) | 0.09 |
PAD | 6 (6.1) | 1 (3.1) | 2 (6.1) | 3 (9.1) | 0.6 |
