Table 2 Univariate and multivariate Cox proportional hazards models for the occurrence of new cardiovascular events in the 2-year follow-up period for 98 chronic hemodialysis patients.

From: Association between ADAMTS13 deficiency and cardiovascular events in chronic hemodialysis patients

Variables

Univariate

Multivariatea

Hazard ratio (95% CI)

p

Hazard ratio (95% CI)

p

ADAMTS13 activity (%)

0.95 (0.92–0.99)

0.01

0.94 (0.90–0.98)

0.003

Age (years)

0.99 (0.95–1.04)

0.7

  

Gender: male versus female

1.68 (0.53–5.34)

0.4

  

Hemodialysis vintage (month)

1.00 (0.99–1.02)

0.8

  

vWF antigen (%)

1.00 (0.99–1.01)

0.7

  

vWF activity (%)

1.00 (0.99–1.01)

0.9

  

White blood cell count (103/ml)

1.07 (0.82–1.39)

0.6

  

Hemoglobin (g/dl)

1.17 (0.71–1.93)

0.5

  

Platelet (103/ml)

1.00 (0.99–1.01)

0.9

  

Albumin (g/dl)

2.07 (0.24–18.02)

0.5

  

Blood urea nitrogen (mg/dl)

1.01 (0.97–1.05)

0.7

  

Creatinine (mg/dl)

0.93 (0.73–1.12)

0.6

  

Calcium (mg/dl),

1.30 (0.68–2.49)

0.4

  

Phosphate (mg/dl)

1.24 (0.79–1.95)

0.3

  

Uric acid (mg/dl)

0.80 (0.53–1.21)

0.3

  

Glucose, fasting (g/dl)

1.00 (0.99–1.01)

0.7

  

HbA1c (%)

1.09 (0.75–1.59)

0.6

  

Cholesterol, total (mg/dl)

1.00 (0.99–1.02)

0.6

  

Triglyceride (mg/dl)

1.00 (0.99–1.01)

0.9

  

HDL (mg/dl)

0.98 (0.94–1.03)

0.4

  

LDL (mg/dl)

1.01 (0.99–1.04)

0.2

  

Ferritin (ug/l)

1.00 (0.99–1.00)

0.3

  

Homocysteine (umole/l)

1.07 (0.98–1.16)

0.1

  

hsCRP (mg/L)

1.02 (1.00–1.04)

0.1

  

Medications (vs. without)

 Statin/ezetimibe

1.92 (0.67–5.48)

0.2

  

 Aspirin

4.39 (1.38–13.99)

0.01

–

–

 Clopidogrel

3.40 (1.19–9.70)

0.02

–

–

 Cilostazol

1.37 (0.18–10.46)

0.8

  

 Unfractionated heparin

0.59 (0.21–1.69)

0.3

  

 LMWH

1.89 (0.65–5.43)

0.2

  

 ACEI/ARB

0.87 (0.35–2.16)

0.8

  

 Beta blocker

1.02 (0.39–2.62)

0.9

  

 CCB

0.77 (0.33–1.82)

0.6

  

Comorbidity (vs. without)

 DM

4.08 (0.91–18.22)

0.07

5.60 (1.15–27.53)

0.03

 Hypertension

4.22 (0.53–33.91)

0.4

  

 CHD

5.70 (1.77–18.17)

0.003

4.27 (1.29–14.09)

0.02

 CVD

2.18 (0.49–9.77)

0.3

  

 PAD

0.46 (0.06–3.86)

0.5

  
  1. vWF = von Willebrand factor, HbA1c = hemoglobin A1c, HDL = high-density lipoprotein cholesterol, LDL = low-density lipoprotein cholesterol, hsCRP = high sensitivity C-reactive protein, LMWH = low molecular weight heparin, ACEI/ARB = angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker, CCB = calcium-channel blocker, DM = diabetes mellitus, CHD = coronary heart disease, CVD = cerebral vascular disease, PAD = peripheral artery disease.
  2. aVariables with a p value < 0.1 in univariate analysis were selected into the multivariate analysis by using the method of “forward stepwise selection” including ADAMTS13 activity, CHD, DM, current uses of clopidogrel and aspirin.
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