Figure 6
Selective activation of targeted fibers through electrical field-shaping. (A) Anode–cathode configurations that resulted in positive behavioral effects show decreased log odds ratios as the current exceeds 2 mA. This decline in performance coincides with increased Cm-Pf fiber activation. (B) Lead locations and numbering scheme of the active contacts for NHP3 positioned within the DTTm target (blue) and anteromedially to the Cm-Pf fibers (orange). (C) Fiber activation profiles for the DTTm (blue) and Cm-Pf fibers (orange) for three configurations in NHP 3 in which the standard monopolar (2-C +) and bipolar (2–3 +) each show early activation of Cm-Pf fibers. These two configurations were not effective in facilitating behavioral performance despite the cathodic contact being in prime position to activate the DTTm. The third configuration, which utilizes field shaping across multiple leads (2–14 +), was one of the most effective configurations because it provided a larger working range of amplitudes that activated the target DTTm before spreading into the Cm-Pf pathway.
