Figure 2
From: Drug repurposing for COVID-19 using graph neural network and harmonizing multiple evidence
(a) COVID-19 knowledge graph t-SNE plot. Two nodes that have similar embedding are closely located in the t-SNE plot. We highlighted drugs undergoing clinical trials (as of July 23, 2020) to glimpse the promising repurposable drugs around the trial drugs. SARS-Cov-2 baits were the upper-left green hexagons. Genes, the gray triangles, were in the middle between baits and drugs. Drugs, the black rounds, were mixed with genes. Drugs undergoing clinical trials, the purple rounds, were closely located together. Phenotypes, the light brown diamonds, were closely located relevant genes and drugs. An interactive plot for a closer look is available in Fig. S2b–e we validated the drug ranking using four different external validation sources including. (b) Differentially expressed genes in SARS-CoV-2-infected human lung cells (GSE153970). (c) GSEA score between the infected human lung cell transcriptome and drug-induced transcriptome. (d) In vitro efficacy (e.g. % inhibition in viral entry and cytopathic effect assays8), and (e) treatment effects in EHRs. Figure (c) was created by Plotly22 (https://plotly.com/).
