Figure 2
From: Mapping the electrostatic potential of the nucleosome acidic patch
Elevated predicted pKa for acidic patch residues in the free H2A-H2B dimer and the nucleosome. Predicted pKa values for acidic patch residues and the two H2B His that line the acidic patch using PROPKA for the solution structures of the Dm. H2A-H2B dimer determined here and the and Hs. dimer (PDB-id 2RVQ) and the nucleosome crystal structure (PDB-id 2PYO). For the solution structures, the average value and standard deviations across all ensemble members are plotted. The reference pKa values for free Asp, Glu and His side chains are indicated as dashed lines.
