Figure 5 | Scientific Reports

Figure 5

From: Two novel human anti-CD25 antibodies with antitumor activity inversely related to their affinity and in vitro activity

Figure 5

The immune cell population analysis after BA9 and BT942 treatment in MC38 tumor in B-hIL2RA mice. (a–e) Quantification of CD4+ T, CD8+ T, Foxp3+ (Treg) and hCD25+Foxp3+ population percentage in MC38 tumors from early phase treatment. CD8+/Treg cell ratios were also analyzed. p values obtained by one-way ANOVA. Data were presented as mean ± SEM. (f,g,h,i,j) Quantification of CD4+ T, CD8+ T, Foxp3+ (Treg) and hCD25+Foxp3+ population percentage in tumors from late phase treatment. CD8+/Treg cell ratios were also analyzed. p values obtained by one-way ANOVA. Data were presented as mean ± SEM. Bars without labels indicate that no statistical significance was observed.

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