Figure 8 | Scientific Reports

Figure 8

From: Two novel human anti-CD25 antibodies with antitumor activity inversely related to their affinity and in vitro activity

Figure 8

Pharmacokinetic and pharmacodynamic characteristics of BT942 in healthy cynomolgus monkeys. (a) Two healthy cynomolgus monkeys were administered intravenously at a single dose of 10 mg/kg with BT942. Enzyme-linked immunosorbent assay (ELISA) was used to determine the concentration of BT942 in serum. ELISA experiment was performed in triplicates. The main PK kinetic parameters were calculated using Winnolin software. Data were presented as mean ± SEM. (b) The peripheral blood before and after administration were collected from monkeys, and then the percentage of CD4+CD25+Foxp3+ cells in peripheral blood at different time points was analyzed with flow cytometry (CytomicsTM FC500). Data were presented as mean ± SEM.

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