Figure 4
From: The novel BET inhibitor UM-002 reduces glioblastoma cell proliferation and invasion
UM-002 reduces invasion of GBM cells into cerebral brain organoids. (A) GBM cell distance to the nearest organoid surface. Boxplots represent individual organoids; data points are individual GBM cells. Distance was normalized by setting the minimum distance for each organoid to 0. (B) Normalized stacked kernel density estimation (KDE) of GBM cell distance to organoid surface. (C) Number of GBM cells whose distance to the surface of the organoid exceeded the invasion threshold defined as the average third quartile value of the DMSO group. Statistical comparisons performed using a one-way ANOVA test with Tukey HSD post-hoc; ** ≤ 0.005; *** ≤ 0.001. Data shown are from three independent biological replicates.
