Figure 6
From: The novel BET inhibitor UM-002 reduces glioblastoma cell proliferation and invasion
UM-002 treatment reduces the proportions of the most proliferative clusters of tumor cells in vivo. (A) UMAP of GBM22 cell transcriptomes captured from DMSO and UM-002-treated orthotopic xenografts, colored by unsupervised shared nearest neighbor (SNN) clustering. (B) Pie charts depicting relative proportions of cells within cell-cycle phases of each SNN cluster, annotations are percentages. (C) Connected bar plot showing the relative proportions of cells assigned to each SNN cluster within tumors treated with DMSO or UM-002. (D) Bar plot of change in relative percentage composition of each cluster in UM-002 treated tumors compared to DMSO treated control tumors.
