Table 1 MICs of MTD12813, RTD-1 and antibacterial drugs (μg/ml).
From: A host-directed macrocyclic peptide therapeutic for MDR gram negative bacterial infections
Strain ID | K. pneumoniae | E. coli | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BAA-1705 | BAA-2146 | 700603 | BAA-1706 | BAA-2340 | BAA-2471 | ML35 | ||||||||
MDR factor | KPC-2 | NDM-1 | ESBL | none | KPC-2 | NDM-1 | none | |||||||
MTD12813 | 6.25 | > 100 | 6.25 | > 100 | 6.25 | > 100 | 3.13 | > 100 | 6.25 | > 100 | 3.13 | 100 | 3.13 | > 100 |
RTD-1 | > 100 | > 100 | 100 | > 100 | > 100 | > 100 | > 100 | > 100 | 50 | > 100 | 25 | > 100 | 25 | > 100 |
Meropenem | 50 | 50 | 100 | > 100 | < 0.78 | < 0.78 | 1.56 | < 0.78 | 6.25 | 6.25 | 50 | > 100 | < 0.78 | < 0.78 |
Imipenem | > 100 | 12.5 | > 100 | 25 | < 0.78 | < 0.78 | 3.13 | < 0.78 | 25 | 6.25 | 50 | 25 | < 0.78 | < 0.78 |
Colistin | < 0.78 | < 0.78 | < 0.78 | < 0.78 | < 0.78 | < 0.78 | < 0.78 | < 0.78 | < 0.78 | < 0.78 | < 0.78 | < 0.78 | < 0.78 | < 0.78 |
Polymyxin B | < 0.78 | < 0.78 | < 0.78 | < 0.78 | < 0.78 | < 0.78 | < 0.78 | < 0.78 | < 0.78 | < 0.78 | < 0.78 | < 0.78 | < 0.78 | < 0.78 |
