Table 3 Steady-state serum C/D Ratio of VPA between CYP2C19 metabolic types.

From: Effect of CYP2C19 polymorphisms on serum valproic level acid in Chinese Han patients with schizophrenia

metabolic types

N

VPA C/D ratio (μg/ml/g)

mean

SD

SE

95% CI

Homozygous EMs (*1/*1)

118

90.96

46.46

4.28

82.49–99.43

heterozygous EMs (*1/*2、*1/*3)

137

131.51 a

48.15

4.11

123.38–139.65

PMs (*2/*2、*2/*3、*3/*3)

41

141.89 a

65.06

10.16

121.35–162.43

  1. ap < 0.01 compared with Homozygous Ems; power (1 – β) = 0.8486 at type I level of 0.05.
  2. EMs: extensive metabolizers; PMs: poor metabolizers; *1/*1: 681GG, 636GG; *1/*2: 681GA, 636GG; *1/*3: 681GG, 636GA; *2/*2: 681AA, 636GG; *2/*3: 681GA, 636GA; *3/*3: 681GG, 636AA.
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