Figure 4
From: A novel paper MAP method for rapid high resolution histological analysis
Visualization of hippocampal vasculature in rodent brains via Paper-MAP. (a) Lectin immunostaining of 5xFAD mouse brain tissues at 3 and 9 months compared to wildtype, processed via Paper-MAP. Enlarged photos (5 × 2 panels, horizontal × vertical tiles) are of hippocampal region. Yellow arrowheads indicate hemolytic plaques. Scale bars (green, 1000-μm; yellow, 100-μm). Quantification of blood vessel length (b), volume (c) and volume/length (d) in 5xFAD and wildtype hippocampus at 3 and 9 months. Quantification of total vessel length from different ratio combinations. Data are presented as mean ± SD (standard deviation); n = 5 for each experimental group. Illustration of mechanism is visualized by PowerPoint v2016.
