Figure 3
Scatter blots representing regression models of disease duration, EDSS score and number of relapses before start of NTZ over time. Linear regression models of disease duration (A), EDSS score (B) and number of previous relapses from disease onset (C) at time of NTZ treatment start from 2006 to 2020. EDSS score at NTZ treatment start and number of relapses before NTZ significantly decreased over time reflecting change of clinical practice. Significance (p) and Pearson correlation coefficient (r) of regression models: (A) p = 0.139, r = − 0.71. (B) p = 0.002, r = −0.198. (C) p < 0.001, r = − 0.263.
