Figure 2

Rain plot of metabolites significantly decreased with increased Procalcitonin. Correlations between procalcitonin levels and individual metabolite abundance at day 0, 3 or 7 were determined utilizing linear regression models correcting for age, SAPS II, admission diagnosis, 25(OH)D at day 0 and for absolute change in 25(OH)D level at day 3. The magnitude of beta coefficient estimates is shown by a color fill scale and the corresponding significance level (− log₁₀(q-value)) is represented by size of the circle. The intensity of the blue fill color represents a decrease in effect size for that metabolite relative to procalcitonin level. All metabolites shown are significant by a q-value threshold of 0.05. All respective β coefficients and q-values can be found in tabular form in Supplementary Data S3. (A) Lysophosphatidylcholines (B) Long chain acylcarnitines.