Table 2 Univariate and multivariate analysis of OS in the patients with chemotherapy and without chemotherapy.

From: Association between chemotherapy and prognostic factors of survival in hepatocellular carcinoma: a SEER population-based cohort study

Variables

Non-chemotherapy(n = 546)

Chemotherapy(n = 546)

 

Univariate analysis

Multivariate analysis

 

Univariate analysis

Multivariate analysis

N

P value

HR(95%CI)

P value

N

P value

HR(95%CI)

P value

Sex

        

 Female

113

 

Reference

 

116

 

—

 

 Male

433

0.0772

0.847 (0.610–1.175)

0.320

430

0.430

—

—

Age at diagnosis, n (%)

        

  < 59 years

260

 

Reference

 

244

 

Reference

 

 59–66 years

174

0.0954

1.229 (0.917–1.649)

0.168

173

0.390

1.158 (0.875–1.533)

0.306

 66–74 years

112

0.9629

1.032 (0.755–1.409)

0.844

129

0.160

1.175 (0.860–1.607)

0.312

Race

        

 White

369

 

—

 

367

 

—

 

 Black

78

0.772

—

—

77

0.460

—

—

 Others

99

0.788

—

—

102

0.510

—

—

AJCC

        

 I

207

 

Reference

 

219

 

Reference

 

 II

204

0.357

1.646 (1.191–2.276)

0.002**

185

0.748

1.356 (0.992–1.855)

0.057

 III

89

 < 0.001***

2.502 (1.729–3.620)

 < 0.001***

96

 < 0.001***

1.809 (1.264–2.587)

0.001**

 IV

46

 < 0.001***

3.326 (2.203–5.021)

 < 0.001***

46

 < 0.001***

2.479 (1.604–3.833)

 < 0.001***

Tumor size

        

  < 3.5 cm

255

 

Reference

 

249

 

Reference

 

 3.5–7.2 cm

184

 < 0.001***

1.359 (0.986–1.872)

0.061

184

 < 0.001***

1.523 (1.119–2.072)

0.008**

  > 7.2 cm

107

 < 0.001***

1.989 (1.337–2.957)

 < 0.001***

113

 < 0.001***

2.220 (1.496–3.294)

 < 0.001***

AFP

        

 Negative

159

 

Reference

 

172

 

Reference

 

 Positive

387

0.186

1.038 (0.784–1.375)

0.793

374

0.0499*

1.434 (1.081–1.901)

0.012*

Fibrosis score

        

 F0

130

—

123

Reference

 F1

416

0.358

—

—

423

0.046*

1.066 (0.780–1.458)

0.69

Grade

        

 Well differentiated

171

 

Reference

 

175

 

Reference

 

 Moderately differentiated

272

0.0941

1.466 (1.092–1.967)

0.011*

279

0.980

1.226 (0.922–1.630)

0.161

 Poorly differentiated

96

 < 0.001***

1.947 (1.349–2.809)

 < 0.001***

87

0.00756**

1.578 (1.097–2.269)

0.014*

 Undifferentiaed

7

0.045*

3.892 (1.496–10.128)

0.005**

5

0.246

1.732 (0.604–4.968)

0.307

Surgery

        

 No surgery

219

 

Reference

 

225

 

Reference

 

 Hepatectomy

108

 < 0.001***

0.151 (0.100–0.228)

 < 0.001***

105

 < 0.001***

0.361 (0.254–0.514)

 < 0.001***

 Hepatectomy and transplant

153

 < 0.001***

0.122 (0.078–0.190)

 < 0.001***

145

 < 0.001***

0.154 (0.098–0.242)

 < 0.001***

 Others

66

 < 0.001***

0.431 (0.286–0.650)

 < 0.001***

71

0.004

0.681 (0.479–0.968)

0.032*

Radiotherapy

        

 No

496

 

Reference

 

497

 

Reference

 

 Yes

50

 < 0.001***

0.603 (0.410–0.885)

0.010**

49

 < 0.001***

1.288 (0.878–1.887)

0.195

  1. *Two-sided P values < 0.05.
  2. **Two-sided P values < 0.01.
  3. ***Two-sided P values < 0.001.
  4. OS, overall survival; HR, hazard ratio; CI, coindidence intervals; AJCC, American Joint Committee on Cancer (7th).
  5. F0, fibrosis score 0–4, non to moderate fibrosis; F1, fibrosis score 5–6, severe fibrosis and cirrhosis.
Back to article page