Figure 8

Gene expression profiles (heatmaps) at branchpoint-1 (A) and branchpoint-2 (B), and expression profiles for ABCC3, SPP1, and S1000A6 along the progression pseudotime (C). Correlation of the expression of ABCC3 and S1000A6 with DNA methylation and de-methylation signatures using the TCGA LUAD datasets (D).