Figure 1 | Scientific Reports

Figure 1

From: Medium levels of transcription and replication related chromosomal instability are associated with poor clinical outcome

Figure 1

Regulatory elements, non-B DNA (NBD) and DNA repeats are hotspots. (A) Random Breakage Model: hotspots are defined as DNA elements containing more BP than expected under RBM and more than surrounding regions. Hscore profile for DNA elements and sliding windows upstream and downstream for (B) Non-B DNA: R-Loops Forming Sequences (RLFS), a-Phased Repeats (APR), Direct Repeats (DR), G-quadruplex (GQ), Inverted Repeats (IR), Mirror Repeats (MR), Short Tandem Repeats (STR), Z-DNA (Z) and (C) DNA repeats: MicroSatellites (MS), Low Complexity DNA (LC), Simple Repeats (SR), Self-Chains Segements-self-aligned (SCS-S) Self-Chains Segements-Gaped (SCS-G), Long terminal repeats (LTR), RetroTransposons (RT), (D) regulatory elements: CpG islands (CpGi), Cis-Regulatory Modules (CRM), Dnase Hyper sensitive sites (DHS) of type dyadic (DHS_dyadic), Enhancer (DHS_enh), Promoter (DHS_prom), other types (DHS_rest). Horizontal red dashed line corresponds to Hscore threshold of 3 for hotspotness. (A) was drawn using LibreOffice Impress 1:6.0.7ubuntu0.18.04.10.

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