Table 3 Human dopamine D1, D2, D3, and D4 and vasopressin V1A receptor binding data of isoliquiritigenin.

From: Isoliquiritigenin, a potent human monoamine oxidase inhibitor, modulates dopamine D1, D3, and vasopressin V1A receptors

Receptors

Radioligand

% Inhibition of control-specific bindinga

Reference antagonist

Reference IC50b

D1

[3H]SCH23390

96.0

SCH23390

0.5

D2L

[3H]methylspiperone

21.3

(+)Butaclamol

2.6

D3

[3H]methylspiperone

52.2

(+)Butaclamol

4.1

D4

[3H]methylspiperone

44.8

Clozapine

93

V1A*

[3H]AVP

60.8

[d(CH2)51,Tyr(Me)2]-AVP

1.4

  1. *Agonist binding.
  2. aValues are presented as the mean of the percent inhibition of control specific binding by 100 µM isoliquiritigenin performed in duplicate.
  3. bThe IC50 value of the reference antagonist (nM).
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