Table 2 Description of the patients’ features.
Patient variable | Biological/clinical characteristics | References |
|---|---|---|
IP10 (Cytokine/Signaling molecule) | IP10 (Interferon gamma-induced protein 10) is secreted in response to IFN-γ by various cells including monocytes, endothelial and fibroblasts. (i) Acts as chemoattractant for monocytes/macrophages, T cells, NK (natural killer) cells, and dendritic cells. (ii) Promotes T cell adhesion to endothelial cells. (iii) Antitumor activity (iv) Inhibition of bone marrow colony formation (v) Angiogenesis | |
GLSZM-ZSV (Tumor PET Imaging features/Radiomics) | Radiomics features: the zone-size variance (ZSV) feature of a gray-level size zone matrix (GLSZM) is defined as \(\frac{1}{{N_{g} \times L_{z} }}\mathop \sum \limits_{{N_{g} }}^{i = 1} \mathop \sum \limits_{{L_{z} }}^{j = 1} \left( {jp\left( {i,j} \right) - \mu_{j} } \right)^{2}\), refer to Appendix A5 of Ref.34 for the Notations | |
Tumor gEUD (tumor radiation) | Generalized equivalent uniform dose (gEUD) of tumor converted from EQD2 (Equivalent Dose at standard 2 Gy per fraction) dose distribution: \(gEUD = \left( {\mathop \sum \limits_{i} \nu_{i} {\text{eqd}}_{2}^{a} } \right)^{\frac{1}{a}}\) and \({\text{eqd}}2 = N_{frac} \times d \times \frac{d + \alpha /\beta }{{2 + \alpha /\beta }}\) where \(\alpha /\beta\) = 10 Gy, is the radiation fractionation sensitivity of cell, a = − 10 is an organ specific parameter, and \(\nu\) is the fractional organ volume obtained from the 3D dose distribution | |
Lung gEUD (lung radiation) | Generalized equivalent uniform dose (gEUD) of lung converted from EQD2 (Equivalent Dose at standard 2 Gy per fraction) dose distribution: \(gEUD = \left( {\mathop \sum \limits_{i} \nu_{i} {\text{eqd}}_{2}^{a} } \right)^{\frac{1}{a}}\) and \({\text{eqd}}2 = N_{frac} \times d \times \frac{d + \alpha /\beta }{{2 + \alpha /\beta }}\) where \(\alpha /\beta\) = 4 Gy, and a = 1 | |
Cxcr1-Rs2234671 (genetics) | A single nucleotide polymorphism (SNP) in the gene cxcr1, also known as Interleukin 8 receptor alpha (IL8RA), related to radiation induced toxicity in non-small cell lung cancer. SNP is a substitution of single nucleotide that occurs at a specific position in the genome via mutation |
