Table 1 Relative mRNA abundances of hepatic genes involved in endocannabinoid and fat metabolism.

From: Effects of endocannabinoids on feed intake, stress response and whole-body energy metabolism in dairy cows

Gene

NaCl

AEA

2AG

P-value

Treatment

ACAA2

0.99 ± 0.06

0.99 ± 0.06

1.01 ± 0.06

0.96

ACACA

0.82 ± 0.19

1.25 ± 0.19

1.14 ± 0.21

0.29

CNR1

1.38 ± 0.22

0.96 ± 0.22

1.05 ± 0.24

0.39

CPT1A

1.09 ± 0.10

0.94 ± 0.10

1.04 ± 0.11

0.43

DGAT1

1.13 ± 0.25

0.92 ± 0.25

1.38 ± 0.27

0.47

DGAT2

1.21 ± 0.25

1.04 ± 0.25

1.19 ± 0.27

0.87

FAAH

1.13 ± 0.08

0.96 ± 0.08

0.97 ± 0.09

0.23

GRP55

1.12 ± 0.19

0.97 ± 0.19

1.20 ± 0.20

0.70

HADH

1.04 ± 0.06

0.96 ± 0.06

1.03 ± 0.07

0.61

PLAAT5

1.38 ± 0.42

1.31 ± 0.42

1.36 ± 0.45

0.99

MGLL

0.97 ± 0.16

1.16 ± 0.16

1.01 ± 0.17

0.65

PPARA

1.09 ± 0.19

1.32 ± 0.19

0.87 ± 0.21

0.31

SREBF1

1.13 ± 0.11

1.11 ± 0.11

0.86 ± 0.12

0.22

  1. Liver tissue samples were obtained from cows treated with NaCl (n = 7), AEA (n = 7) or 2AG (n = 6) for 9 days.
  2. ACAA2, acetyl-COA acyltransferase 2; ACACA, acetyl-CoA carboxylase alpha; CNR1, cannabinoid receptor 1; CPT1A, carnitine palmitoyltransferase 1A; DGAT1/ 2, diacylglycerol O-acyltransferase 1/ 2; FAAH, fatty acid amide hydrolase; GPR55, G protein-coupled receptor 55; HADH, hydroxyacyl-CoA dehydrogenase; PLAAT5, phospholipase A and acyltransferase 5; MGLL, monoglyceride lipase; PPARA, peroxisome proliferator activated receptor alpha; SREBF1, sterol regulatory element binding transcription factor 1.
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