Figure 8 | Scientific Reports

Figure 8

From: In vivo melanin 3D quantification and z-epidermal distribution by multiphoton FLIM, phasor and Pseudo-FLIM analyses

Figure 8

Modulation of z-epidermal distribution with skin color ITA grade and skin ethnicity in constitutive pigmentation study. Melanin density z-epidermal distribution profiles (mean 3D melanin density estimated in 12 thickness-normalized epidermal layers from 1—DEJ level to 12—SC level) of (a) different skin color ITA groups and b) different skin ethnicity. The insert in (b) is showing the z-profiles of different skin color ITA groups for Asiatic and European origins. The z-profiles data are expressed as mean ± confidence intervals of the mean. Raw 2PEF intensity images (cyan hot) and Pseudo-FLIM melanin masks (white) extracted from multiphoton z-stacks acquired on ventral forearms of volunteers with (c) light and (d) tanned skin color ITA groups. DEJ – dermal–epidermal junction level, SB - stratum basale, SS – stratum spinosum, SG - stratum granulosum and SC - stratum corneum.

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