Figure 4 | Scientific Reports

Figure 4

From: miR1908-5p regulates energy homeostasis in hepatocyte models

Figure 4

miR1908-5p mimic reduces ME1, G6PD and the NADPH/NADP+ ratio. Lysates from HuH-7 cells and primary hepatocytes treated with miR1908-5p or control were assayed for the presence of a, G6PD, ME1 by qRT-PCR or b, NADPH and NADP+. In (a) MIM vs MIMctl differences were all statistically significant (Student’s t-test < 0.05). In (b) Matched samples from each biologic are linked by a line. Treatment with miR1908-5p was associated with a reduction in the ratio of NADPH/NADP+ (0.84 ± 0.06; p = 0.007, paired t-test).

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