Figure 9
From: miR1908-5p regulates energy homeostasis in hepatocyte models
miR1908-5p interacts with cognate target mRNA to regulate the cellular energy landscape. miR1908-5p affects energy (NADP) homeostasis and sensing. miR1908-5p abundance is under the influence of glucose abundance and AMPK activity. In turn, miR1908-5p reduces LKB1 and AMPK levels and activity, in part via LKB1 transcript inhibition, while inhibiting mTOR and AKT. This is correlated with reduced ACC1 phosphorylation which is predicted to increase its activity and promote fatty acid synthesis. Increased fatty acid synthesis may however be counteracted by reduced NADPH availability due to lower G6PD and ME1 expression. Red and green highlights indicate reduced or increased activation and/or level, respectively as a result of miR1908-5p action.
