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Figure 1

From: Inference of tissue relative proportions of the breast epithelial cell types luminal progenitor, basal, and luminal mature

Figure 1

(a) DNA methylation: a methyl group is added to some cytosine DNA bases, giving tissue and cell-type specific patterns at the genome-wide scale that allow accurate inference of cell-type proportions in bulk-tissue genomic (i.e., convolved) data. (b) We use a two-step procedure to first estimate the reference matrix X, before second estimating the mixing matrix W (representing the cell-type proportions). (c) DNAme data are used to estimate general cell-type proportions with an earlier tool1, before DNAme and RNA-seq data are used to estimate breast epithelial subtype proportions. Illustration by Christoph Bock, Max Planck Institute for Informatics; adapted under licence CC BY-SA 3.0 from https://en.wikipedia.org/wiki/DNA_methylation.

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