Figure 2 | Scientific Reports

Figure 2

From: Immunoreactivity of the SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in murine models of hormonal manipulation, ageing, and cardiac injury

Figure 2

ACE-2 and TMPRSS-2 immunoreactivity in lung alveoli in murine models of ageing and hormonal manipulation. The violin plots provide information on the full data distribution. The horizontal black line indicates the median of the kernel density plot. (A) ACE-2 immunoreactivity in young (left panel) and aged (right panel) control animals, gonadectomized animals, and gonadectomized animals receiving long-term hormone replacement. (B) TMPRSS-2 immunoreactivity in young (left panel) and aged (right panel) control animals, gonadectomized animals, and gonadectomized animals receiving long-term hormone replacement. Ordinal logistic regression was performed to test the association between the level of expression of ACE-2 and TMPRSS-2 with age, sex, and hormonal status. The resulting p-values are reported in the box. ACE-2, angiotensin-converting enzyme 2; Gx, gonadectomy; HR, hormone replacement; TMPRSS-2, transmembrane protease serine 2.

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