Table 2 List of microRNA showing significant difference in patients with type 2 diabetes and liver cancer.

From: Detection of increased serum miR-122-5p and miR-455-3p levels before the clinical diagnosis of liver cancer in people with type 2 diabetes

 

Stage 1 Microarray study

Stages 2 + 3 Validation by qPCR

microRNA

†Non-T2D without cancer

†T2D without cancer

†T2D with liver cancer

Fold Change (T2D with liver cancer vs T2D without cancer)

P value (T2D with liver cancer vs. T2D without cancer)

ANOVA P value

#T2D without cancer (N = 1888)

#T2D with liver cancer (N = 127)

#T2D with other non-liver cancer (N = 487)

Fold Change (T2D with liver cancer vs T2D without cancer)

P value (T2D with liver cancer v. T2D without cancer)

P value (T2D with liver cancer vs T2D without cancer plus T2D with non-liver cancer)

ANOVA P value

miR-548a-3p

2.91 ± 1.10

2.35 ± 0.77

1.53 ± 0.77

−1.76

0.0020

3.98E-5

       

miR-3201

2.55 ± 1.17

2.68 ± 1.19

1.66 ± 0.98

−2.02

0.0050

0.0125

       

miR-122-5p

1.12 ± 0.70

1.06 ± 1.35

2.65 ± 2.87

3.01

0.0014

0.0005

32.86 ± 3.29

84.00 ± 23.11

38.46 ± 12.67

2.55

0.030*

0.035*

0.010

Log of miR-122-5p

      

0.45 ± 0.02

1.19 ± 0.07

0.43 ± 0.05

 

 < 0.001

 < 0.001

0.011

miR-455-3p

6.49 ± 1.47

6.27 ± 1.84

4.58 ± 2.03

−3.22

0.0107

0.0075

1.02 ± 0.31

9.39 ± 5.85

0.59 ± 0.26

9.21

0.156*

0.152*

 < 0.001

Log of miR-455-3p

      

−2.55 ± 0.03

−1.42 ± 0.14

−2.31 ± 0.07

 

 < 0.001

 < 0.001

 < 0.001

miR-4532

6.35 ± 1.32

7.23 ± 2.15

8.40 ± 1.87

2.26

0.0117

0.0085

305.44 ± 100.39

3833.09 ± 2888.09

181.35 ± 72.92

12.55

0.225*

0.221*

 < 0.001

Log of miR-4532

      

0.18 ± 0.03

0.68 ± 0.11

0.48 ± 0.05

 

 < 0.001

 < 0.001

 < 0.001

  1. †The expression levels from the microarray study were presented as mean ± standard deviation in log2 scale.
  2. #The qPCR data were presented as mean ± standard deviation.
  3. *Unpaired t-test with Welch’s correction was used for the analysis.
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