Scientific Reports

Table 4 AP-MS analysis of identified proteins in MYCL-MB2-WT using cell lysates from reprogrammed HDFs and hiPSCs.

From: MYCL promotes iPSC-like colony formation via MYC Box 0 and 2 domains

(i) Proteins enriched more than two-fold in MYCL-MB2-WT compared with MYCL-MB2-W96E (reprogramming HDFs) (31)
*HNRNPA1*	*HNRNPD*	*HNRNPDL*	*HNRNPA2B1*	*HNRNPA0*	*HNRNPA3*
*KHDRBS1*	*HNRNPAB*	*ALYREF*	*DDX5*	*HNRNPU*	*SYNCRIP*
*HNRNPR*	*HNRNPK*	*DDX17*	*C1QBP*	FAU	RPL22
RPL37A	RPL23A	NCL	RPS24	RPL31	RPS4X
RPS7	CIRBP	MCFD2	KBTBD3	COPG2	PTGES3
SIKE1
	Italic value	RNA binding proteins
	Bold italic value	: RNA processing proteins

(ii) Proteins enriched more than two-fold in MYCL-MB2-WT compared with MYCL-MB2-W96E (hiPSCs) (60)
*HNRNPA1*	*HNRNPD*	*HNRNPDL*	*HNRNPA2B1*	*HNRNPA0*	*HNRNPA3*
*KHDRBS1*	*HNRNPAB*	*ALYREF*	*DDX5*	*HNRNPU*	*SYNCRIP*
*HNRNPR*	*HNRNPK*	*PRPF31*	*DDX42*	*LYAR*	*YBX1*
FAU	RPL22	RPL37A	RPL23A	NCL	RPS24
RPL31	RPS4X	RPS7	CIRBP	RPL23	RPL30
LSM14A	DDX18	NSUN2	ILF3	TRMT1	SRP9
IGF2BP1	SRP14	ANP32A	ILF2	HACD3	UBE2N
GPC4	MDK	BAX	ANP32E	ANP32B	APEX1
PTGES3	MCFD2	CFDP1	ACTR2	ITGB1	SFRP1
DSTN	PDHB	HADHA	HADHB	NDUFS5	CNBP
	Italic value	RNA binding proteins
	Bold italic value	: RNA processing proteins

(iii) Common enriched proteins enriched between reprogramming HDFs and hiPSCs (25)
*HNRNPA1*	*HNRNPD*	*HNRNPDL*	*HNRNPA2B1*	*HNRNPA0*	*HNRNPA3*
*KHDRBS1*	*HNRNPAB*	*ALYREF*	*DDX5*	*HNRNPU*	*SYNCRIP*
*HNRNPR*	FAU	RPL37A	RPL22	RPL23A	CIRBP
RPS24	RPS7	RPS4X	RPL31	NCL	PTGES3
MCFD2
	Italic value	RNA binding proteins
	Bold italic value	: RNA processing proteins

Three groups are described: (i) protein interactors whose peptide counts increased in reprogramming HDFs more than two-fold in MYCL-MB2-WT than MYCL-MB2-W96E; (ii) protein interactors whose peptide counts increased in hiPSCs more than two-fold in MYCL-MB2-WT compared to MYCL-MB2-W96E; and (iii) commonly identified proteins. n = 1.

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