Figure 4

MMP-1 tissue remodeling mediator secretion following ISO WS and VP exposures, by exposure condition. Data are median, IQR, and range, and the laboratory color coded points represent the mean of each laboratory results. (A) MMP-1 concentrations. (B) MMP-1 concentrations normalized to NRU viability. Abbreviations: AIR, air control; ALI, air–liquid interface control; INC, incubator control; ISO, International Organization for Standardization; MMP-1, matrix metalloproteinase 1; VP, vapor phase; WS, whole smoke. Graphs were generated with R version 3.4.3 (2017-11-30) and edited by using GIMP image manipulation program (version 2.10.14).