Figure 7

MMP-1 tissue remodeling mediator secretion following HCI WS and VP exposures, by exposure condition. Data are median, IQR, and range, and the laboratory color coded points represent the mean of each laboratory results. (A) MMP-1 concentrations. (B) MMP-1 concentration-normalized to NRU viability. The laboratory color coded points represent the mean of each laboratory result. Abbreviations: AIR: Air control, ALI, air–liquid interface control; HCI, Health Canada intense regimen; INC: Incubator control with apical media, NRU, neutral red uptake; VP, vapor phase; WS: Whole smoke. Graphs were generated with R version 3.4.3 (2017-11-30) and edited by using GIMP image manipulation program (version 2.10.14).