Figure 1



RNAseq analysis of control and PCX-overexpressing Ishikawa cells. (A) Heat-map of all differentially expressed genes between control (CON) and PCX-overexpressing (PCX-OE) Ishikawa cells. Normalized gene expression values (Transcripts Per Million, TPM) are outlined in each heatmap. (B–E) Heat-map of differentially expressed genes associated with KEGG gene pathways (https://www.genome.jp/kegg/pathway.html) for cell adhesion and junction. Each pathway is labelled with the KEGG pathway database ID (e.g. “Cell adhesion molecules” has the KEGG pathway ID 4514) (B) Cell adhesion molecules. (C) Tight junction. (D) Adherens junction. (E) Gap junction. For each, proportions of up- (Up, in blue) and down-regulated (Down, in red) genes are also shown by a pie chart.