Table 1 Results of the evaluation of the biological activities of various members of the trisubstituted carborane compound library.
From: Comprehensive exploration of chemical space using trisubstituted carboranes
Scaffold | Compound | HIF-1[a] | RABV[b] | HeLa cells | N2a cells |
|---|---|---|---|---|---|
| Ia | > 30 | > 9 | > 30 | > 30 |
Ib | > 30 | > 9 | > 30 | > 30 | |
Ic | > 30 | > 9 | > 30 | > 30 | |
Id | > 30 | > 9 | > 30 | > 30 | |
Ie | > 30 | > 9 | > 30 | > 30 | |
If | > 30 | > 9 | > 30 | > 30 | |
| IIa | > 30 | > 9 | > 30 | > 30 |
IIb | > 30 | 5.74 | > 30 | > 30 | |
IIc | > 30 | 6.87 | > 30 | > 30 | |
IId | > 30 | 3.30 | > 30 | > 30 | |
IIe | > 30 | 8.14 | > 30 | > 30 | |
IIf | > 30 | 5.78 | > 30 | > 30 | |
IIg | > 30 | 8.37 | > 30 | > 30 | |
IIh | > 30 | > 9 | > 30 | > 30 | |
| IIIa | > 30 | > 9 | > 30 | > 30 |
IIIb | 26.3 | > 9 | > 30 | > 30 | |
IIIc | > 30 | > 9 | > 30 | > 30 | |
IIId | 23.0 | > 9 | > 30 | > 30 | |
IIIe | > 30 | > 9 | > 30 | > 30 | |
IIIf | > 30 | > 9 | > 30 | > 30 | |
IIIg | > 30 | > 9 | > 30 | > 30 | |
IIIh | > 30 | > 9 | > 30 | > 30 | |
| IVa | > 30 | > 9 | > 30 | > 30 |
IVb | 17.4 | 5.96 | > 30 | > 30 | |
IVc | > 30 | > 30 | > 30 | > 30 | |
IVd | > 30 | > 30 | > 30 | > 30 | |
| Va | > 30 | 3.87 | > 30 | > 30 |
Vb | > 30 | 2.17 | > 30 | > 30 | |
Vc | > 30 | 4.44 | > 30 | > 30 | |
Vd | > 30 | 3.95 | > 30 | > 30 | |
Ve | > 30 | 3.46 | > 30 | > 30 | |
Vf | > 30 | 2.56 | > 30 | > 30 | |
Vg | > 30 | 5.08 | > 30 | > 30 | |
Vh | > 30 | 4.00 | > 30 | > 30 | |
Vi | 5.46 | Activation | 16.7 | > 30 | |
Vj | 3.24 | Activation | > 30 | 22.6 | |
Vk | 3.64 | Activation | 15.0 | 21.2 | |
Vl | 18.1 | Activation | 21.7 | 25.2 | |
Vm | 23.2 | > 9 | > 30 | > 30 | |
Vn | > 30 | > 9 | > 30 | > 30 | |
Vo | 9.21 | Activation | 20.9 | 7.90 | |
Vp | > 30 | Activation | > 30 | 8.00 |
