Figure 2 | Scientific Reports

Figure 2

From: Activation of efficient DNA repair mechanisms after photon and proton irradiation of human chondrosarcoma cells

Figure 2

Cell cycle analysis. (a) Heatmap blot of RNA sequencing data of relevant cell cycle regulator genes presented in log2 fold‑change after photon (X-ray 6 Gy; left) and proton (4 Gy; right) IR (n = 3). (b) Cells were analysed using flow cytometry 1 h, 4 h, 8 h, and 24 h after X-ray or proton IR. The corresponding statistical evaluation shown in stacked bar charts (n = 5). 4 h and 8 h after proton IR the cells are clearly arrested in the G2/M phase, whereas after 24 h this effect is largely reversed. X-ray irradiated cells showed hardly any effects. (c) Representative original tracks of non-IR control cells (ctrl) and the photon X-ray respectively proton irradiated samples (4 Gy) are shown.

Back to article page